Figure 5.

Cytokine production by novel ILCs. C10 and C2 skew towards NK-type cytokines. Lineage Negative (CD3, CD14, CD19), CD34⁻CD45⁺ cells were activated with PMA/Ionomycin for 6 h. Cytokine production was assessed via intracellular labeling. (A) Representative gating scheme of CD56^Bright CD94⁺CD16⁻CD127⁻CD49a⁻ (C10), CD49⁺ (C2), and of CD56^DimCD16⁺CD127⁻CD117⁻ from the decidua basalis showing NK type cytokine production (B–E) Quantification of NK type cytokine production by C10, C2, and cNK. Decidua basalis, n = 24; decidua parietalis, n = 9. Data represented as max/min, median, and 25 and 75th percentiles. Statistical significance was determined by ANOVA, followed by Tukey post-hoc tests. *p < 0.05, **p < 0.005, ****p < 0.00001. For statistical details see Supplementary Table 5. Data is provided in Data Sheet 1.