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. 2020 Jan 30;11:594. doi: 10.1038/s41467-019-14036-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic illustration and delivery process of the nanoinhibitor, BIP-MPC-NP, enhancing TMZ sensitivity against glioma via intravenous injection. b The schematic diagram revealing the establishment and structure of nanoinhibitors. c The transmission electron microscope (TEM) images of the nanoinhibitors. Scale bar = 50 nm. d The dynamic light scattering (DLS) measurements of BIP-NP and BIP-MPC-NP. e Fluorescence images presenting the co-localization of FITC-MBP and RhB-EBP for each BIP-MPC-nanoparticle. Scale bar = 15 μm. f Förster resonance energy transfer (FRET) analysis of BIP-MPC-NP and MBP/EBP/MPC-NP. g The zeta potential data of BIP-NP and BIP-MPC-NP (n = 3). h The quantitative analysis of peptide fragments per nanoinhibitor (n = 5). i The ratio of EBP and MBP on the nanoparticles (n = 5). j TEM micrograph exhibited the oxygen element (O), nitrogen element (N) and phosphorus element (P). Scale bar = 25 nm. The error bars in g, h and i represent the S.D. of three or five measurements.