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. 2020 Jan 30;11:594. doi: 10.1038/s41467-019-14036-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The fluorescence assays showed the localization of EBP-MPC-NP, MBP-MPC-NP or BIP-MPC-NP on the LN229R cell surface. The gray value was displayed in line plots. Scale bar = 50 μm. b The flow cytometric analysis of cells with MPC-NP, EBP-MPC-NP, MBP-MPC-NP or BIP-MPC-NP in vitro (n = 3). c The transportation assays showed the permeability of EBP-MPC-NP, MBP-MPC-NP and BIP-MPC-NP in vitro (n = 3). d The binding affinity of MPC-NP, EBP-MPC-NP, MBP-MPC-NP or BIP-MPC-NP after penetrating BBB models. Scale bar = 25 μm. e The IF assays showed the attenuation of p-EGFR and p-MET by administration of MPC-NP, EBP-MPC-NP, MBP-MPC-NP or BIP-MPC-NP in BBB model. Scale bar = 25 μm. f Ex vivo fluorescence and bioluminescence images of the visceral organs after the injection of BIP-NP or BIP-MPC-NP in mice. g, h The histogram summarized the relative luminescence intensity and the relative fluorescence intensity of tumor-bearing brains. The error bars in b, c, g and h represent the S.D. of three measurements (n = 3). P value is determined by Student’s t-test. Significant results are presented as NS non-significant, **P < 0.01, or ***P < 0.001.