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. 2020 Jan 30;11:594. doi: 10.1038/s41467-019-14036-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a The EGFR, p-EGFR, MET and p-MET expression in TMZ-resistant glioma cells treated with different nanoinhibitors. b The levels of EGFR and MET dimers in TMZ-resistant glioma cells treated with BIP-MPC-NP. c The heatmap displayed the differential expressed proteins between GBM patients with low EGFR and MET copy numbers group and with high EGFR and MET copy numbers group. The Sankey diagram displayed the Gene Ontology of the differentially expressed proteins. d The inhibition of DNA damage repair modules expression and the increase of γH2AX expression with the treatments of TMZ and different nanoinhibitors in LN229R, U87MGR and HG9R. e The boxplots showing the statistics of comet assay of TMZ-resistant glioma cells with TMZ and different nanoinhibitors (n = 50). In the box plots, bounds of the box spans from 25 to 75% percentile, center line represents median, and whiskers visualize minimum and maximum of the data points. P value is determined by Student’s t-test. Significant results are presented as ***P < 0.001.