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. 2020 Jan 30;11:594. doi: 10.1038/s41467-019-14036-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a The diagram showed the process of the establishment of models, drug administration and MRI scan. T2-weighted MR images of mouse head at selected times post treatment with TMZ and different nanoinhibitors. The tumor sizes were visualized by H&E staining image. b Tumor volumes were measured on selected days post tumor implantation (n = 10). c Kaplan–Meier survival curves of mouse models after corresponding treatments (n = 10). P = 4.33E−10 for the four groups. Control vs TMZ, P = 9.04E−01; Control vs TMZ + EBP, P = 4.22E−04; Control vs TMZ + MBP, P = 3.40E−04; Control vs TMZ + BIP, P = 4.00E−06; TMZ vs TMZ + EBP, P = 4.13E−02; TMZ vs TMZ + MBP, P = 6.20E−05; TMZ vs TMZ + BIP, P = 4.00E−06; TMZ + EBP vs TMZ + MBP, P = 1.57E−01; TMZ + EBP vs TMZ + BIP, P = 1.32E−02; TMZ + MBP vs TMZ + BIP, P = 4.82E−03. The error bars in b represent the S.D. of ten measurements. P value is determined by Student’s t-test or log-rank test. Significant results are presented as *P < 0.05, **P < 0.01 or ***P < 0.001.