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. 2020 Jan 30;10:1493. doi: 10.1038/s41598-020-58438-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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EGFR and BIRC5 expression are negatively associated with metastasis-free survival in patients with basal-like tumors. Using an 855-patient breast cancer dataset, patients with basal-like tumors (N = 140) were divided into four groups based on expression levels of EGFR and BIRC5: EGFR^highBIRC5^high, EGFR^highBIRC5^low, EGFR^lowBIRC5^high, EGFR^lowBIRC5^low. Kaplan-Meier curves were generated to assess the effect of high versus low expression of the two genes on (a) liver relapse-free survival, (b) lung relapse-free survival, and (c) metastasis-free survival (MFS) time. Log-rank tests were performed to determine statistical significance (*p < 0.05, **p < 0.01); p-values are listed in Supplementary Table S6.