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. 2020 Jan 30;10:1493. doi: 10.1038/s41598-020-58438-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dose responses of basal-like TNBC PDXs to selected classes of targeted therapeutics. Graphs depict cell viability (percent of vehicle) in response to increasing concentrations of the indicated drugs for each of four basal-like PDX lines (HCI01, UCD52, WHIM30, WHIM2): (a) proteasome inhibitors (carfilzomib, bortezomib, ixazomib); (b) drugs targeting apoptosis pathways (YM155, navitoclax, ABT-199, embelin, birinapant); and (c) EGFR inhibitor (afatinib), CDK4/6 inhibitor (abemaciclib), SSRI (fluoxetine), synthetic vitamin D3 (calcitriol), antiarrhythmic (dronedarone). Experiments were performed in triplicate. Error bars represent standard deviation between independent experiments. p-values are listed in Supplementary Table S1.