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. 2020 Jan 24;10:1577. doi: 10.3389/fphar.2019.01577

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Copyright © 2020 Gao, Yang, Wang, Sun, Chen, Zhu and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The pooled RR of adverse events. Notes: The black diamond indicates the estimated RR for each RCT. The gray box around each diamond indicates the estimated weight of each RCT, and the extending lines indicate the estimated 95% CI of RR for each RCT. The diamond indicates the estimated RR (95% CI) for all patients together. (A) Any adverse event. (B) Nausea. (C) Urinary tract infection. (D) Dizziness. (E) Serum AST or ALT above ULN. Weights are from a random-effects analysis. Abbreviations: CI, confidence interval; RCT, randomized controlled trial; RR, relative risk.