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. 2020 Jan 30;11:589. doi: 10.1038/s41467-020-14470-2

Fig. 7. TJP1 deficiency enhances insulin sensitivity.

Fig. 7

a–e Effect of Tjp1 LKO on nuclear PER1 levels evaluated by immunoblots a, statistical analysis of PER1 b, and CRY1 c in Nucl., statistical analysis of Rev-Erbα in TCL d, and Rev-Erbα expression e in liver extracts from mice fed on a RD or HFD for 16 weeks. n = 5 mice. f–i Effect of Tjp1 LKO on blood glucose f, plasma insulin levels g, plasma triglyceride levels h and hepatic triglyceride contents i from mice fed on a RD or HFD for 16 weeks. TGs triglycerides. n = 8 mice. j Hematoxylin and eosin staining of liver from WT and Tjp1 LKO mice fed on a RD or HFD for 16 weeks. Scale bar, 50 μm. k–o Glucose infusion rate (GIR, k), glucose disposal rate (GDR, l), percentage suppression of HGP m, insulin-stimulated GDR (IS-GDR, n) and percentage of free fatty acid (FFA) suppression o from WT and Tjp1 LKO mice fed on a RD or HFD for 16 weeks. n = 6 mice. Data are shown as mean ± s.e.m. Comparison of different groups was carried out using two-way ANOVA. *P < 0.05, **P < 0.01, ***P < 0.001. Source data are provided as a Source Data file.