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. 2020 Jan 24;10:1630. doi: 10.3389/fphar.2019.01630

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Copyright © 2020 Carpagnano, Sessa, Scioscia, Lacedonia, Foschino, Venuti, Triggiani, Valenzano, Resta, Cibelli and Messina

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Two groups were enrolled: biological treatment group (BT group) and traditional treatment group (TT group). The BT group was further subdivided under drug criteria: omalizumab group and mepolizumab group. All groups were tested at different times: T0 (first administration of the biologic agent); T1 (after 1 month); T3 (after 3 months); T6 (after 6 months).