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. 2020 Jan 30;11(1):78. doi: 10.1038/s41419-020-2281-y

Fig. 4. Caspase-1 deficiency inhibits trophoblast pyroptosis and AT1R antigen exposure in PE mice and trophoblast model.

Fig. 4

a Effect of caspase-1 knockout on trophoblast death in PE mice. TUNEL analysis in placenta was shown. Bar = 50 μm. Effect of caspase-1 knockout on IL-1β and IL-18 levels in serum (b) and placenta (c) of PE mice. IL-1β and IL-18 were detected by ELISA. Results are expressed as means ± SEM (n = 7 mice in each group). **P < 0.01 and ***P < 0.001 versus control group, ††P < 0.01 and †††P < 0.001 versus LPS group, one-way ANOVA with S-N-K posttest. d Effect of caspase-1 knockdown on trophoblast apoptosis. Cell apoptosis was detected by using flow cytometry. e Effect of caspase-1 knockdown on trophoblast IL-1β and IL-18 levels. IL-1β and IL-18 were detected by ELISA. f Effect of caspase-1 knockdown on trophoblast AT1R exposure. AT1R was detected by WB. Results are expressed as means ± SEM from three independent experiments. **P < 0.01 and ***P < 0.001 versus control group, †P < 0.05 and ††P < 0.01 versus LPS group, one-way ANOVA with S-N-K posttest.