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. 2020 Jan 30;10:1485. doi: 10.1038/s41598-020-58448-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hit validation for invasion and migration. The top seven common hits from the siRNA confirmatory and CRISPR confirmatory screens were further assessed by CRISPR in PANC-1 cells for (A) invasiveness using cell invasion assay, (B) migration using cell migration assay. The data presented are based on three independent experiments.