Table 2.
Percent conservation and frequency of amino acids per position of the RVC20 epitope across 1412 unique full-length RABV G sequences in GenBank.
| Position | Consensus | BSAa (Å2) | Conservation (%) | Observed amino acid counts |
|---|---|---|---|---|
| 42 | S | 27 | 99.9 | S-1411, P-1 |
| 44 | M | 41 | 99.1 | M-1399, I-7, L-4, V-2 |
| 47 | K | 10 | 99.9 | K-1410, R-2 |
| 186 | G | 43 | 99.1 | G-1399, R-10, E-3 |
| 187 | T | 33 | 99.3 | T-1402, M-8, K-1, A-1 |
| 188 | S | 50 | 99.4 | S-1404, P-5, Y-2, F-1 |
| 189 | C | 67 | 99.9 | C-1411, R-1 |
| 190 | D | 79 | 98.1 | D-1385, N-27 |
| 191 | I | 23 | 99.9 | I-1411, T-1 |
| 192 | F | 22 | 99.7 | F-1408, L-3, S-1 |
| 194 | N | 47 | 87.8 | N-1240, T-77, S-61, Y-33, K-1 |
| 225 | L | 12 | 99.1 | L-1399, M-10, V-2, I-1 |
| 226 | K | 74 | 99.6 | K-1406, M-3, R-3 |
| 227 | L | 28 | 100.0 | L-1412 |
| 228 | C | 49 | 99.9 | C-1411, S-1 |
| 229 | G | 67 | 100.0 | G-1412 |
| 230 | V | 38 | 99.8 | V-1409, I-3 |
| 231 | L | 16 | 76.4 | L-1078, P-192, S-140, H-1, T-1 |
aBuried surface area, as determined by the PDBePISA web server33.