Table 1.
Demographics and biomarkers data from the different cohorts.
| n | Age | Sex (f/m) | t-Tau (pg/mL) | p-Tau (pg/mL) | Amyloid β42 (pg/mL) | Lipocalin 2 (pg/mL) | |
|---|---|---|---|---|---|---|---|
| Cohort 1 | |||||||
| ND | 73 | 67 ± 10 | 40/33 | 232 ± 207 | 40 ± 11 | 719 ± 351 | 771 ± 347 |
| AD | 47 | 67 ± 10 | 26/21 | 591 ± 435 | 90 ± 51 | 449 ± 207 | 691 ± 247 |
| VaD | 27 | 72 ± 8 | 17/10 | 386 ± 445 | 44 ± 15 | 779 ± 348 | 2233 ± 1326 |
| MD | 31 | 74 ± 10 | 25/6 | 444 ± 272 | 76 ± 54 | 437 ± 206 | 1565 ± 833 |
| LBD | 36 | 69 ± 11 | 18/18 | 385 ± 301 | 56 ± 42 | 513 ± 292 | 917 ± 398 |
| FTD | 21 | 65 ± 12 | 8/13 | 373 ± 370 | 57 ± 21 | 665 ± 251 | 762 ± 331 |
| CJD | 54 | 68 ± 10 | 27/27 | 5936 ± 5914 | 61 ± 18 | 635 ± 324 | 1037 ± 661 |
| SVDND | 20 | 63 ± 14 | 9/11 | 181 ± 135 | 34 ± 16 | 787 ± 229 | 753 ± 300 |
| VCIND | 7 | 66 ± 9 | 2/5 | 177 ± 59 | 48 ± 12 | 1114 ± 220 | 946 ± 366 |
| Cohort 2 | |||||||
| ND | 24 | 64 ± 8 | 12/12 | 168 ± 74 | 35 ± 14 | 913 ± 409 | 713 ± 232 |
| AD | 15 | 68 ± 6 | 6/9 | 602 ± 336 | 71 ± 27 | 417 ± 95 | 660 ± 182 |
| VaD | 10 | 69 ± 10 | 3/7 | 330 ± 236 | 38 ± 13 | 768 ± 188 | 1440 ± 979 |
| Cohort 3 | |||||||
| ND | 15 | 67 ± 13 | 7/8 | 193 ± 57 | 33 ± 9 | 684 ± 123 | 753 ± 386 |
| AD | 27 | 72 ± 6 | 16/11 | 647 ± 307 | 88 ± 29 | 435 ± 81 | 709 ± 236 |
| VaD | 16 | 74 ± 6 | 10/6 | 402 ± 300 | 55 ± 23 | 501 ± 134 | 1381 ± 953 |
| Cohort 4 | |||||||
| AD | 28 | 72 ± 10 | 21/7 | 595 ± 234 | 86 ± 25 | 634 ± 228 | 634 ± 198 |
| SVDND | 3 | 71 ± 8 | 1/2 | 135 ± 37 | 27 ± 9 | 953 ± 55 | 613 ± 258 |
| VCIND | 8 | 67 ± 5 | 3/5 | 174 ± 45 | 38 ± 12 | 869 ± 328 | 845 ± 277 |
| VaD | 10 | 76 ± 6 | 3/7 | 248 ± 66 | 43 ± 11 | 932 ± 221 | 1131 ± 481 |
Number of cases (n), age (mean ± standard deviation), sex (female/male), CSF biomarkers total-Tau, p-Tau and amyloid beta 42 and CSF LCN2 (mean ± standard deviation in pg/mL) are indicated.
ND non-primarily neurodegenerative and non-ischemic neuropsychiatric diseases, AD Alzheimer’s disease, VaD vascular dementia, MD mixed dementia, LBD Lewy body dementia, FTD frontotemporal dementia, CJD sporadic Creutzfeldt-Jakob disease, SVDND small vessel disease no dementia, VCIND vascular cognitive impairment no dementia.