Fig. 7.

RNA-sequencing analysis. (a) Heat map and hierarchical clustering of the RNA-seq data from FD-1-VECs, FD-1-VECs+agal, WT-VECs, FD-1-Cor-VECs, and FD-1-TSP-1^−/- VECs. (b) Heat map of the significant transcriptional changes in metabolism-associated genes. (c) Transcriptional expression of oxidative stress-associated genes as measured by qPCR. The data are expressed as means ± SEM (n = 2). * p < 0.05; ** p < 0.01**; *** p < 0.001. (d) Oxygen consumption rates in FD-VECs as measured with a Seahorse XF24 analyzer. (e) A schematic model for vasculopathy in FD-VECs.