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. 2020 Jan 9;23(2):100829. doi: 10.1016/j.isci.2020.100829

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Induction of LTD in Human Neurons

(A) Raw traces of eEPSCs recorded in a non-ChR2-expressing GABA neuron. Top panel: raw traces before and after LFS. Bottom panel: raw traces before and after LFS in the presence of AP-5.

(B) The amplitude of light-evoked EPSCs before and after LFS in the absence and presence of AP-5 during the 30-min recording.

(C) Time course of changes in percentage of eEPSCs before and after LFS in the absence and presence of AP-5.

(D) Averaged amplitude of eEPSCs before and after LFS in the absence (p < 0.05, n = 9, mean ± SEM, t test) and presence of AP-5 (p > 0.05, n = 14). Inset: Full distribution of the change of eEPSC amplitude from 26 cells studied in the LTD protocol.

(E) The effect of LTD protocols on the frequency of mEPSCs in non ChR2-expressing GABA neurons. Left, representative mEPSCs of a GABA neuron before and after the LTD protocol. Right, the averaged mEPSC frequency in GABA neurons before and after the LTD protocol (p < 0.05, n = 6, mean ± SEM, t test).