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. 2020 Jan 9;23(2):100829. doi: 10.1016/j.isci.2020.100829

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Induction of LTP/LTD in DS Patient iPSC- and Isogenic iPSC-Derived Neural Networks

(A) Cartoon of the co-culture between DS/isogenic glutamate neurons and hESC-derived GABA neurons.

(B) Averaged amplitude of eEPSCs before and after pairing protocol in DS patient iPSC- (p > 0.05, n = 16, mean ± SEM, t test) and isogenic iPSC-derived neural network (p < 0.05, n = 7, mean ± SEM, t test).

(C) Change in the amplitude of light-evoked EPSCs before and after pairing protocol over 30-min recording.

(D) The percentage increase of light-evoked EPSCs before and after pairing protocol.

(E) Averaged amplitude of eEPSCs before and after LFS in DS patient iPSC- (p > 0.05, n = 8, mean ± SEM, t test) and isogenic iPSC-derived neural network (p < 0.05, n = 4, mean ± SEM, t test).

(F) Change in the amplitude of light-evoked EPSCs before and after LFS over 30-min recording.

(G) The percentage decrease of light-evoked EPSCs before and after LFS.