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. 2020 Jan 24;10:3077. doi: 10.3389/fimmu.2019.03077

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Copyright © 2020 Trus, Udenze, Berube, Wheler, Martel, Gerdts and Karniychuk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Infection phenotypes of CpG-recoded ZIKV variants in pregnant mice. (A) The pregnancy rate in mated and plugged mice (n = 8 dams, Control; n = 12, WT; n = 9, E+102CpG; n = 11, E/NS1+176CpG). ZIKV loads in the uterus (B) and spleen (C) of bred, non-pregnant mice. (D) The percentage of fetal resorption (n = 32 fetuses, Control; n = 15, WT; n = 35, E+102CpG; n = 33, E/NS1+176CpG). (E) ZIKV loads in the placenta. (F) Maternal ZIKV-specific IgG (quantified by immunoperoxidase monolayer assay—IPMA) and neutralizing (quantified by virus-neutralizing assay—VN) Abs in the pregnant subgroup. Asterisk (*) denotes a statistically significant difference compared to the WT ZIKV group. Dotted lines represent the LOD, solid lines represent mean values.