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. 2020 Jan 24;10:3077. doi: 10.3389/fimmu.2019.03077

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Copyright © 2020 Trus, Udenze, Berube, Wheler, Martel, Gerdts and Karniychuk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Age-dependent ZAP expression in brain tissues of mice. (A) ZAP expression in different age groups (n = 8–11 healthy animals). (B) ZAP expression in neonatal mouse groups inoculated with different ZIKV variants at 1 day and sampled at 21 days after birth (n = 4–11). (C) Negative staining control. (D) Fetal brain. (E) Neonatal cerebellum. (F) Adult cerebellum. Focal staining in neonatal (G) and adult (H) white matter. Diffuse staining in neonatal (I) and adult (J) white matter. The scale bar is 100 μm.