Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Pharmacokinetics of compounds 21 and 31 in rats and mice
| Compound | Species | Route (Dose) | t1/2 (h) | Cmax (ng/mL) | AUC0-t (ngh/mL) | Vss (L/kg) | CL (L/h/kg) | F (%) |
|---|---|---|---|---|---|---|---|---|
| 21 | Rat | PO (25 mg/kg) | 1.7 | 1396.7±277.4 | 13444.7±933.4 | - | 1.9 | |
| 31 | Rat | IV (5 mg/kg) | 2.4 | - | 6343 | 2.0 | 0.79 | - |
| Rat | PO (25 mg/kg) | 2.9 | 7333 | 29547 | - | 0.88 | 93% | |
| Mouse | IV (5 mg/kg) | 0.5 | - | 3688.8 | 2.75 | 1.36 | - | |
| Mouse | PO (25 mg/kg) | 1.60 | 983.1 | 9135 | - | - | 50% |
