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. 2020 Jan 24;8:4. doi: 10.3389/fbioe.2020.00004

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Copyright © 2020 Saeed, Dmour and Taha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Confocal and wide-field fluorescence microscopy images showing MCF-7 cells treated with DOX-loaded (A) CP-PPA NPs, (B) CROSS-CP-PPA NPs, (C) CPS-HMP NPs, (D) CROSS-CPS-HMP NPs, (E) MCF-7 cells treated with free DOX, and (F) untreated cells (control). All treatments are equivalent to 1.0 μM doxorubicin over 4 h periods. White arrows point nanoparticles up taken into cellular cytoplasm. Scale: 10 μm.