Table 5.
LCs of MB-loaded NPs (mg/g).
| NPs | Total LC (mg MB per g polymer)a | ||||
|---|---|---|---|---|---|
| Crosslinker | Polymer | At 10:1 Polymer to MB ratio | At 1:1 Polymer to MB ratio | ||
| TPP | C | 0.39 ± 0.05 | 7.33 ± 0.05 | ||
| CP | 1.97 ± 0.11 | p = 0.0002b | 18.31 ± 1.20 | p = 0.0001b | |
| CROSS-CPc | 4.57 ± 0.18 | 27.31 ± 0.62 (2.5 ± 0.05)d |
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| PPA | C | 1.08 ± 0.02 | 10.87 ± 1.75 | ||
| CP | 2.02 ± 0.07 | p = 0.0010b | 37.19 ± 0.67 | p = 0.030b | |
| CROSS-CPc | 8.55 ± 0.35 | 62.05 ± 6.28 (3.9 ± 0.09)d |
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| HMP | C | 1.33 ± 0.16 | 10.94 ± 0.96 | ||
| CPS | 4.63 ± 0.33 | p = 0.9080b | 100.30 ± 2.24 | p = 0.022b | |
| CROSS-CPSc | 4.66 ± 0.75 | 111.40 ± 1.58 (8.1 ± 0.02)d |
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a
Each value represents the average of triplicate measurements± standard deviation.
b
p-value Calculated using t-test with 5% significance for LC difference between covalent and corresponding ionotropic nanoparticles.
c
EDC covalently stabilized NPs.
d
NPs core loading determined through acid degradation (HCl, 2.0 M) of covalent NPs.