Table 5.
Descriptive analysis of patients’ demographics and ICSI outcomes by MI/oocyte cutoff.
| MI/oocyte ≤10.5% (n=2,399) | MI/oocyte >10.5% (n=1,521) | p | |
|---|---|---|---|
| Patient’s demographics | |||
| Maternal age (years) | 36.10±4.82 | 35.77±4.41 | 0.034 |
| Maternal BMI (kg/m2) | 24.29±3.81 | 24.39±3.88 | 0.060 |
| Paternal age (years) | 38.54±6.60 | 38.41±6.26 | 0.530 |
| Total gonadotropin administered (IU) | 2477.61±986.76 | 2453.75±770.55 | 0.431 |
| Estradiol level at hCG trigger day (pg/mL) | 1869.45±1797.94 | 2060.45±1820.42 | 0.051 |
| Interval between hCG and oocyte retrieval (hours) | 35.34±0.41 | 35.34±0.43 | 0.733 |
| COS outcomes* | |||
| Follicles (n) | 14.80±0.22 | 16.49±0.27 | <0.001 |
| Retrieved oocytes (n) | 10.09±0.16 | 11.22±0.19 | <0.001 |
| Oocyte yield (%) | 68.29±0.41 | 69.71±0.52 | 0.034 |
| MII Oocytes (n) | 8.74±0.42 | 6.97±0.52 | <0.001 |
| MI Oocytes (n) | 0.37±0.02 | 2.28±0.25 | <0.001 |
| GV Oocytes (n) | 1.39±0.37 | 1.27±0.45 | 0.024 |
| MII/oocytes (%) | 86.23±0.37 | 64.51±0.46 | <0.001 |
| MI/oocytes (%) | 1.69±0.22 | 24.87±0.27 | <0.001 |
| GV/oocytes (%) | 11.82±0.32 | 10.45±0.39 | 0.007 |
| Laboratorial outcomes** | |||
| Fertilization rate (%) | 83.15±0.44 | 80.47±0.55 | <0.001 |
| Embryos obtained (n) | 6.85±0.59 | 6.35±0.074 | <0.001 |
| High-quality embryos rate at day 2(%) | 27.0±0.50 | 23.7±0.60 | <0.001 |
| High-quality embryos rate at day 3 (%) | 49.20±0.60 | 47.70±0.70 | 0.130 |
| Blastocyst rate (%) | 47.8±0.70 | 47.5±0.80 | 0.767 |
| Transferred embryos (n) | 1.69±0.23 | 1.87±0.28 | <0.001 |
| Endometrial thickness (mm) | 10.62±0.53 | 10.78±0.65 | 0.046 |
| Clinical outcomes*** | |||
| Implantation rate (%) | 32.24±2.37 | 30.54±0.70 | 0.038 |
| Clinical pregnancy rate (%) | 43.72 | 22.25 | <0.001 |
| Miscarriage rate (%) | 13.69 | 14.79 | 0.651 |
hCG: human chorionic gonadotropin;
IU: international units.
*
Data was adjusted for maternal age, maternal BMI and total FSH dose.
**
Data was adjusted for maternal age, maternal BMI, total FSH dose, estradiol level at hCG trigger day and number of retrieved oocytes.
***
Data was adjusted for maternal age, maternal BMI, total FSH dose, estradiol level at hCG trigger day, number of retrieved oocytes, number of transferred embryos and endometrial thickness.