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. 2020 Jan 29;16:1744806920903848. doi: 10.1177/1744806920903848

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© The Author(s) 2020

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — D-4F abolishes mechanical hypersensitivity evoked by a ROS source and 4-HNE. (a–d) Measurement of mechanical and thermal hypersensitivity at indicated time points in rats after local injection of the ROS equivalent H₂O₂ (a and b; 19.2 µM) or 4-HNE (c and d; 6 µM) plus D-4F (2.5 mg/kg i.p.) or saline. Filled symbols indicate D-4F treatment; open symbols for vehicle groups. N = 6/group. Two-way repeated-measurement ANOVA, post hoc Holm–Sidak; *P < 0.05 highlighting significant differences between treatments at indicated time points. 4-HNE: 4-hydroxynonenal; H₂O₂: hydrogen peroxide; D-4F: D-amino-4-phenylalanine mimetic peptide of apolipoprotein A-I.