Table 1.
Cancer subtype | Cell line | Mutation | SNPs genotype | Other described mutations | ||
---|---|---|---|---|---|---|
rs1867277 | rs965513 | Poly Alanine | ||||
PTC | BCPAP | BRAF V600E | G/G | A/A | 14/14 | p53 D259Y/AKT1 copy gain |
PTC | K1 | BRAF V600E | A/A | A/A | 16/16 | PI3KCA E542K |
PTC | KTC1 | BRAF V600E | G/A | G/A | 14/14 | – |
PTC | NIM | BRAF V600E | G/G | G/A | 14/14 | – |
PTC | TPC1 | RET/PTC1 | G/G | G/G | 14/14 | – |
FTC | FTC-133 | PTEN R130* | A/A | A/A | 16/16 | p53 R273H |
FTC | ML-1 | – | G/G | G/G | 14/14 | p53 frameshift |
FTC | TT206-C09 | NRAS | G/A | G/G | 14/14 | p53 R273C |
FTC | WRO | BRAF V600E | A/A | G/A | 14/16 | – |
ATC | 8505c | BRAF V600E | G/G | G/G | 14/14 | p53 R248G |
ATC | C643 | HRAS | A/A | G/G | 14/14 | p53 R248Q and K286E |
ATC | Cal62 | KRAS | G/G | G/G | 14/14 | p53 A161D |
ATC | HTH7 | NRAS | A/A | G/G | 14/16 | p53 G245S |
ATC | HTH83 | HRAS | G/A | G/G | 12/14 | – |
ATC | KTC2 | BRAF V600E | G/G | G/G | 14/14 | – |
ATC | OCUT2 | BRAF V600E | G/G | G/G | 14/14 | PI3KCA H1047R |
ATC | SW1736 | BRAF V600E | A/A | G/G | 14/16 | p53 Null |
ATC | T235 | BRAF V600E | G/G | G/G | 14/14 | – |
ATC | T238 | BRAF V600E | A/A | G/G | 16/16 | p53 S183*/PI3KCA E542K |
– | NThyORI | – | G/G | G/A | 14/14 | – |
The genotypes of the rs1867277, rs965513 SNPs and the length of the poly-alanine tract are shown in the central columns. The cancer subtype from which the cell lines originated, as well as the driver mutations, is also shown.