Figure 5.

Effect of chemotherapy drug exposure on follicle density/number at each follicular stage. Follicle analysis in Control cultures, or after exposure to Single CIS, Double CIS, Single DOX, Double DOX or Combination CIS + DOX. (A) Density (human – unhatched) or (B) number (mouse – hatched) of follicles at (ai, bi) Primordial, (aii, bii) Transitional and (aiii, biii) Primary/Secondary stage. Data are mean + s.e.m.; unfilled diamonds denote significant differences between Control and a treatment group (individual P values are given in text). For human ovaries, n = 9 in each group; for mouse ovaries, 5–8 ovaries were analysed per treatment group as follows: Control – n = 7, Single CIS – n = 6, Single DOX – n = 6, Double CIS – n = 6, Double DOX – n = 5, CIS + DOX – n = 8). Primord – primordial follicles; Trans – transitional follicles; 1°/2° – primary/secondary follicles; Comb – Combination.