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Potential molecular mechanism by which NGF regulates myelin clearance and axon regeneration following PNI. Exogenous NGF binds to the p75NTR in SC to activate the AMPK/mTOR signing pathway to enhance autophagy and drive autophagic flux. This dynamic regulation process in SCs promotes engulfing and degradation of myelin fragments, thus shortening the time of myelin remodeling and axon growth for injured peripheral nerve.
