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. 2020 Jan 1;10(4):1733–1745. doi: 10.7150/thno.36022

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Heatmaps depicting measured circulatory parameters over a log-time axis. In each case, darker colors represent lower relative measurements, and the 0 timepoint indicates pre-ligation. While US (red) measures perfusion of the deep tissue (~ 6 mm), LSCI (orange) measures perfusion within 1mm of the tissue surface. Hypoxia (yellow) and α_Vβ₃ (green) expression were both measured using SPECT imaging with the targeted probes ^99mTc-BRU-5921 and ^99mTc-NC100692, respectively. HIF-1α (blue) and CD31 (purple) expression in ischemic tissue were quantified from immunohistochemistry images.