Table 1.

Gene expression changes after mitotane treatment of control cells or after development of resistance (selection).

Gene	Log2 FC	Exp	Adj P	Comparison
SCARB1	−2.54	7.76	2.4 × 10−20	Resistant DMSO vs Nonresistant DMSO
HSD3B2	−5.77	5.33	5.98 × 10−18	Resistant DMSO vs Nonresistant DMSO
CYP11A1	−3.66	6.45	1.01 × 10−17	Resistant DMSO vs Nonresistant DMSO
CYP21A2	−4.34	6.61	7.49 × 10−17	Resistant DMSO vs Nonresistant DMSO
IGF1	4.24	5.74	2.94 × 10−14	Resistant DMSO vs Nonresistant DMSO
STAR	−3.52	7.14	4.17 × 10−14	Resistant DMSO vs Nonresistant DMSO
AXIN2	1.59	6.87	2.2 × 10−13	Resistant DMSO vs Nonresistant DMSO
SOAT1	−1.95	7.35	1.64 × 10−12	Resistant DMSO vs Nonresistant DMSO
DDIT3	1.55	5.94	2.55 × 10−8	Nonresistant Mitotane vs Nonresistant DMSO
GDF15	1.87	5.9	8.19 × 10−6	Nonresistant Mitotane vs Nonresistant DMSO
SREBF1	−1.14	6.16	8.4  × 10−6	Nonresistant Mitotane vs Nonresistant DMSO
XBP1	0.75	6.96	7.29 × 10−4	Nonresistant Mitotane vs Nonresistant DMSO

Only genes referenced in results section are listed.

Adj P, adjusted P value; DMSO, dimethyl sulfoxide; Exp, average expression; Log₂ FC, log2 fold change.