. 2019 Dec 17;9(1):55–62. doi: 10.1530/EC-19-0502
This work is licensed under a Table 3.
Univariate and multivariate influence of thyroid status on the primary endpointa split by baseline eGFR category.
| eGFR <45, n = 656 | eGFR 45–60, n = 1933 | eGFR >60, n = 2275 | ||||
|---|---|---|---|---|---|---|
| Subcl hyperth vs euth (n = 14 vs 615) | Subcl hypo vs euth (n = 27 vs 615) | Subcl hyperth vs euth (n = 35 vs 1830) | Subcl hypo vs euth (n = 68 vs 1830) | Subcl hyperth vs euth (n = 60 vs 2128) | Subcl hypo vs euth (n = 87 vs 2128) | |
| No. of events (%) | 6 (33.3) vs 123 (18.8) | 8 (20.5) vs 123 (18.8) | 4 (12.9) vs 280 (15.0) | 8 (7.8) vs 280 (15.0) | 4 (9.8) vs 338 (16.0) | 16 (13.0) vs 338 (16.0) |
| Univariate HR (95% CI) | 0.72 (0.18–2.93) | 1.13 (0.50–2.56) | 0.37 (0.09–1.47) | 0.28 (0.09–0.88)b | 0.55 (0.23–1.33) | 1.10 (0.64–1.87) |
| Age and sex adjusted HR (95% CI) | 0.79 (0.20–3.12) | 1.18 (0.52–2.69) | 0.36 (0.09–1.43) | 0.27 (0.09–0.86)b | 0.54 (0.22–1.31) | 1.10 (0.65–1.89) |
| Multivariate adjusted HR (95% CI) | 1.07 (0.26–4.40) | 1.41 (0.57–3.51) | 0.25 (0.03–1.76) | 0.24 (0.06–0.95)b | 0.54 (0.20–1.45) | 1.43 (0.83–2.46) |
Multivariate adjusted analysis include prespecified variables: country, age, gender, use of pravastatin, history of vascular disease, history of diabetes mellitus, history of hypertension, current smoking, alcohol in units/week, BMI, total cholesterol/HDL-ratio, albumin.
aPrimary endpoint includes coronary heart disease death or non-fatal myocardial infarction or fatal or non-fatal stroke; bP-value of hazard ratio <0.05.
CI, confidence interval; HR, hazard ratio.