Table 1.
Demographic and clinical characteristics of the patients.
| LC (n = 286) | LCC (n = 288) | P | |
|---|---|---|---|
| Age (mean ± SD, years) | 50.7 ± 12.2 | 55.7 ± 11.4 | <0.001a |
| Gender [n (%)] | |||
| Male | 229 (80.1) | 238 (82.6) | 0.454b |
| Female | 57 (19.9) | 50 (17.4) | |
| Etiology [n (%)] | |||
| HBV | 229 (80.1) | 230 (79.9) | <0.001b |
| Other† | 7 (2.4) | 15 (5.2) | |
| Mixed | 41(14.3) | 15 (5.2) | |
| Unknown | 9 (3.1) | 28 (9.7) | |
| Laboratory blood tests (mean ± SD) | |||
| AFP (μg/L) | 10.9 ± 49.9 | 417.4 ± 551.6 | <0.001a |
| ALT (U/L) | 56.3 ± 185.7 | 57.8 ± 100.3 | 0.901a |
| AST (U/L) | 61.9 ± 119.9 | 88.6 ± 139.1 | 0.014a |
| TBIL (μmol/L) | 35.6 ± 68.3 | 30.0 ± 38.1 | 0.230a |
| DBIL (μmol/L) | 20.5 ± 43.0 | 17.3 ± 28.1 | 0.281a |
| TP (g/L) | 61.0 ± 8.7 | 64.6 ± 7.2 | <0.001a |
| ALB (g/L) | 32.1 ± 5.7 | 35.0 ± 6.5 | <0.001a |
| GLB (g/L) | 28.9 ± 7.3 | 29.6 ± 6.2 | 0.183a |
| GGT (U/L) | 55.0 ± 85.5 | 122.1 ± 145.6 | <0.001a |
| ALP (U/L) | 104.6 ± 77.9 | 162.6 ± 132.2 | <0.001a |
| K+ (mmol/L) | 4.1 ± 0.6 | 4.1 ± 0.6 | 0.243a |
| Na+ (mmol /L) | 138.4 ± 3.8 | 139.0 ± 3.8 | 0.048a |
| Cl− (mmol /L) | 106.2 ± 5.0 | 102.7 ± 4.5 | <0.001a |
| Ca2+ (mmol /L) | 2.1 ± 0.2 | 2.2 ± 0.2 | <0.001a |
| PT (s) | 14.2 ± 3.8 | 13.2 ± 2.3 | <0.001a |
| APTT (s) | 41.4 ± 12.4 | 36.5 ± 9.2 | <0.001a |
| INR | 1.2 ± 0.3 | 1.2 ± 0.2 | 0.056a |
| Child-Pugh grade [n (%)] | |||
| A | 154 (53.8) | 160 (55.6) | 0.029b |
| B | 60 (21.0) | 79 (27.4) | |
| C | 72 (25.2) | 49 (17.0) | |
†
The other causes include hepatitis C, alcoholic liver disease, schistosomiasis.
a
Student t-test.
b
Pearson's Chi-squared test.
LCC, liver cirrhosis with hepatocellular carcinoma; LC, liver cirrhosis; HBV, hepatitis B virus; AFP, alpha-fetoprotein; ALT, alanine aminotransaminase; AST, aspartate aminotransaminase; TBIL, total serum bilirubin; DBIL, direct serum bilirubin; TP, total serum protein; ALB, serum albumin; GLB, serum gamma-globulin; GGT, gamma-glutamyl transferase; ALP, alkaline phosphatase; PT, prothrombin time; APTT, activated partial thromboplastin time; INR, international standardized ratio.