Table 4.

Comparison of the net benefits in clinical decisions regarding the diagnosis of hepatocellular carcinoma in cirrhotic patients with AFP < 400 μg/L.

Pt (%)	Net benefit		Advantage of the model
	Intervention to all patients	Intervention based on the model	Increment of net benefit	Unnecessary intervention avoided per 100 patients
3	0.278	0.278	0.000	0
5	0.263	0.268	0.005	10
8	0.239	0.253	0.014	16
10	0.222	0.241	0.019	17
20	0.125	0.206	0.081	32
30	0.000	0.178	0.178	42
40	−0.167	0.163	0.330	50
50	−0.400	0.135	0.535	54
60	−0.750	0.111	0.861	57
70	−1.333	0.096	1.429	61
80	−2.500	0.060	2.560	64
90	−6.000	0.033	6.033	67
96	−16.50	0.019	16.519	69

Pt, threshold probability; “Increment of net benefit” is calculated as: net benefit of the model – net benefit of intervention to all; “Unnecessary intervention avoided per 100 patients” is calculated as Vickers and Elkin (17): (net benefit of the model – net benefit of intervention to all)/(pt/(1– pt)) × 100.