Table 1:
Changes in oxidative stress parameters in COPD-only patients and patients with comorbid COPD and hypertension depending on polymorphisms in the AGT gene (Me [Lq; Uq]).
| Parameters | Genotypes | н, р | ||
|---|---|---|---|---|
| In all study subjects (n=73) | ||||
| I/I (n=21) | I/D (n=38) | D/D (n=14) | ||
| 8-isoprostane | 136.00 (87.00, 165.00) |
133.00 (47.00, 167.00) |
133.00 (95.00, 162.00) |
H=0.08 р=0.96 |
| Н2О2 | 57.10 (45.20, 83.70) |
57.00 (35.60, 78.90) |
65.90 (44.60, 79.80) |
H=0.98 р=0.61 |
| О2•- | 10.50 (6.40, 15.60) |
10.40 (2.90, 14.80) |
12.35 (7.40, 14.70) |
H=0.65 р=0.72 |
| COPD+hypertension (n=28) | ||||
| I/I (n=9) | I/D (n=12) | D/D (n=7) | ||
| 8-isoprostane | 176.00 (162.00, 189.00) |
172.00 (159.00, 189.50) |
155.00 (134.00, 196.00) |
H=0.21 р=0.90 |
| Н2О2 | 83.90 (82.90, 85.40) |
83.50 (79.55, 86.95) |
79.80 (71.20, 89.60) |
H=0.07 р=0.97 |
| О2•- | 16.10 (15.10, 16.90) |
15.95 (15.10, 17.00) |
14.70 (13.90, 17.30) |
H=0.16 р=0.92 |
| COPD (n=25) | ||||
| I/I (n=7) | I/D (n=14) | D/D (n=4) | ||
| 8-isoprostane | 114.00 (95.00, 149.00) |
143.50 (108.00, 165.00) |
110.00 (101.50, 137.00) |
H=2.53 р=0.28 |
| Н2О2 | 54.10 (46.70, 57.10) |
57.00 (52.10, 64.20) |
51.40 (47.65, 56.40) |
H=2.21 р=0.33 |
| О2•- | 9.60 (7.30, 10.50) |
10.40 (8.70, 11.00) |
9.05 (8.15, 10.05) |
H=2.03 р=0.36 |
| Control (n=20) | ||||
| I/I (n=5) | I/D (n=12) | D/D (n=3) | ||
| 8-isoprostane | 21.00 (16.00, 34.00) |
31.00 (25.50, 44.00) |
39.00 (28.00, 45.00) |
H=2.82 р=0.24 |
| Н2О2 | 21.20 (15.70, 33.40) |
29.80 (24.25, 33.70) |
34.10 (26.70, 34.90) |
H=2.48 р=0.29 |
| О2•- | 1.00 (0.80, 1.80) |
2.15 (1.15, 2.75) |
2.10 (1.80, 2.60) |
H=3.62 р=0.16 |
Note: H = Kruskal-Wallis test; p = the significance test of the latter