Table 2:
Comparative analysis of changes in oxidative stress parameters in COPD-only patients and patients with combined COPD + hypertension within one genotype of the ACE gene.
| Parameters | 8-isoprostane | Н2О2 | О2•- |
|---|---|---|---|
| I/I genotype | |||
| Kruskal-Wallis test and its respective test of significance | Н=15.54; р<0.001* |
Н=17.45; р<0.001* |
Н=17.45; р<0.001* |
| Mann–Whitney U test in pairwise comparison of groups | р1-2=0.005* р2-3=0.003* р1-3=0.004* |
р1-2<0.001* р2-3=0.003* р1-3=0.004* |
р1-2<0.001* р2-3=0.003* р1-3=0.004* |
| I/D genotype | |||
| Kruskal-Wallis test and its respective test of significance | Н=27.08; р<0.001* |
Н=32.43; р<0.001* |
Н=32.85; р<0.001* |
| Mann–Whitney U test in pairwise comparison of groups | р1-2=0.011* р2-3<0.001* р1-3<0.001* |
р1-2<0.001* р2-3<0.001* р1-3<0.001* |
р1-2<0.001* р2-3<0.001* р1-3<0.001* |
| D/D genotype | |||
| Kruskal-Wallis test and its respective test of significance | Н=8.84; р=0.012* |
Н=11.00; р=0.004* |
Н=11.00; р=0.004* |
| Mann–Whitney U test in pairwise comparison of groups | р1-2=0.059 р2-3=0.016* р1-3=0.034 |
р1-2=0.008* р2-3=0.016* р1-3=0.034 |
р1-2=0.008* р2-3=0.016* р1-3=0.034 |
Note 1: р1-2 = the significance test when comparing the COPD+hypertension group with the COPD group; р2-3 = the significance test when comparing the COPD + hypertension group with the control group; р1-3 = the significance test when comparing the COPD group with the control group.
Note 2: The level of statistical significance according to Bonferroni adjustment for intergroup comparison is at p<0.017.
Note 3: * = statistically significant results.