Table 3:
The key parameters of oxidative stress in groups of COPD-only patients and patients with combined COPD and hypertension depending on polymorphisms of theAGT gene (Me [Lq; Uq]).
| Parameters | Genotypes | Н, р | ||
|---|---|---|---|---|
| In all study subjects (n=73) | ||||
| M/M (n=19) | M/T (n=44) | T/T (n=10) | ||
| 8-isoprostane | 118.00 (35.00, 164.00) |
123.50 (49.00, 159.00) |
166.50 (155.00, 176.00) |
H=4.91 р=0.09 |
| Н2О2 | 59.20 (31.80, 80.20) |
55.25 (36.20, 71.15) |
83.30 (71.50, 83.70) |
H=4.93 р=0.08 |
| О2•- | 10.40 (2.60, 15.10) |
9.70 (3.00, 13.95) |
15.50 (13.90, 16.10) |
H=5.77 р=0.06 |
| COPD+hypertension (n=28) | ||||
| M/M (n=7) | M/T (n=13) | T/T (n=8) | ||
| 8-isoprostane | 164.00 (138.00, 196.00) |
178.00 (144.00, 189.00) |
166.50 (159.00, 188.50) |
H=0.01 р=1.00 |
| Н2О2 | 82.90 (71.90, 89.60) |
85.40 (73.50, 87.40) |
83.50 (81.05, 83.80) |
H=0.60 р=0.74 |
| О2•- | 15.80 (13.90, 17.30) |
16.40 (14.20, 16.90) |
15.60 (15.10, 16.85) |
H=0.01 р=1.00 |
| COPD (n=25) | ||||
| M/M (n=6) | M/T (n=18) | T/T (n=1) | ||
| 8-isoprostane | 135.50 (108.00, 162.00) |
126.50 (96.00, 149.00) |
169.00 | H=2.72 р=0.26 |
| Н2О2 | 55.65 (50.70, 60.70) |
55.25 (46.70, 57.20) |
65.80 | H=2.68 р=0.26 |
| О2•- | 9.80 (8.90, 10.90) |
9.70 (7.50, 10.60) |
11.20 | H=2.30 р=0.32 |
| Control (n=20) | ||||
| M/M (n=6) | M/T (n=13) | T/T (n=1) | ||
| 8-isoprostane | 27.00 (26.00, 35.00) |
34.00 (21.00, 41.00) |
12.00 | H=2.97 р=0.23 |
| Н2О2 | 26.25 (24.70, 31.80) |
31.40 (21.20, 34.10) |
12.90 | H=2.96 р=0.23 |
| О2•- | 1.50 (1.20, 2.60) |
2.10 (1.00, 2.50) |
0.50 | H=2.77 р=0.25 |
Note: H = Kruskal-Wallis test; p = the significance test of the latter.