Table 1.
Definitions of thyroid disorders based on SHIP-data and claims data
| Thyroid disorders | Subgroups | Clinical examination (SHIP)a | Billing diagnosisb | |
|---|---|---|---|---|
| laboratory value and measurements | medication (ATC codes) | ICD-10 GM | ||
| Hyperthyroidism | subclinical |
TSH < 0.49 mIU/l fT4 10.10–16.50 pmol/l |
no | E05.- hyperthyroidism |
| clinical manifestation, untreated |
TSH < 0.49 mIU/l fT4 > 16.50 pmol/l |
no | ||
| treated | not considered |
H03BB01 carbimazol H03BB02 thiamazol |
||
| iatrogenic | TSH < 0.49 mIU/l | H03AA.- levothyroxin /combinations | ||
| Hypothyroidism | subclinical |
TSH > 3.29 mIU/l fT4 10.10–16.50 pmol/l |
no |
E02.- subclinical Iodine deficiency hypothyroidism E03.- other hypothyroidism |
| clinical manifestation, untreated |
TSH > 3.29 mIU/l fT4 < 10.10 |
no | ||
| treated | TSH 0.49–3.29 mIU/l | H03AA.- levothyroxin / combination | ||
| potentially undertreated | TSH > 3.29 mIU/l | H03AA.- levothyroxin /combination | ||
| Thyroiditis |
TPO-antibody > 200 IU/ml |
E06.- thyroiditis | ||
| Goitre |
thyroid volume men > 25 ml women > 18 ml |
E01.0 diffuse goitre due to iodine deficiency E01.1 multinodular goitre due to iodine deficiency E01.2 goitre due to iodine deficiency E03.0 congenital hypothyroidism with diffuse goitre E04.0 nontoxic diffuse goitre E04.2 nontoxic multinodular goitre E04.8 other nontoxic goitre E04.9 other not specified nontoxic goitre E05.0 hyperthyroidism with diffuse goitre E05.2 hyperthyroidism with toxic multinodular goitre E07.1 dyshormonogenetic goitre |
||
| Nodular goitre |
thyroid volume men > 25 ml women > 18 ml and at least one nodule |
E01.1 multinodular goitre due to iodine deficiency E04.2 nontoxic multinodular goitre E05.2 hyperthyroidism with toxic multinodular goitre |
||
| Diffuse goitre |
thyroid volume men > 25 ml women > 18 ml and no nodule |
E01.0 diffuse goitre due to iodine deficiency E03.0 congenital hypothyroidism with diffuse goitre E04.0 nontoxic diffuse goitre E05.0 hyperthyroidism with diffuse goitre |
||
| Thyroid nodule | ultrasound examination nodule size < 1 cm or > = 1 cm |
E01.1 multinodular goitre due to iodine deficiency E04.1 nontoxic thyroid nodule E04.2 nontoxic multinodular goitre E05.1 hyperthyroidism with toxic solitary thyroid nodule E05.2 hyperthyroidism with toxic multinodular goitre D34 benign neoplasm of the thyroid |
||
| Thyroid cancer | self-reported (interview) |
C73 malignancy neoplasm of the thyroid D09.3 carcinoma in situ thyroid and other endocrine gland |
||
ATC-Codes Anatomical Therapeutic Chemical Classification, ICD-10 GM International Classification of Disease 10th Revision, German Modification, TSH Thyroid Stimulating Hormone, fT3 free triiodothyronine, fT4 free thyroxine, TPO-antibody Thyroid Peroxidase Antibody
aat the time of SHIP-2 or SHIP-TREND examination
bat least one relevant and confirmed ICD diagnosis coded as acute or permanent diagnosis in the billing data within 5 years prior to the SHIP-2/SHIP-TREND study entrance of the participant