Table 1.
Baseline characteristics of patient cohort
| Variables | Overall | Grade III | Grade IV | p |
|---|---|---|---|---|
| n (%) | 181 | 56 (31) | 125 (69) | – |
| Male, n (%) | 111 (61) | 31 (55) | 80 (64) | 0.348 |
| Ethnicity, n (%) | 0.554 | |||
| Chinese | 126 (70) | 41 (73) | 85 (68) | – |
| Malay | 26 (14) | 9 (16) | 17 (13) | – |
| Indian | 20 (11) | 4 (7) | 16 (13) | – |
| Caucasian | 7 (4) | 2 (4) | 5 (4) | – |
| Others | 2 (1) | 0 | 2 (2) | – |
| Median (IQR) age | 57 (43–66) | 50 (38–64) | 59 (44–67) | 0.017 |
| Median (IQR) preop KPS | 80 (70–80) | 80 (70–80) | 80 (70–80) | 0.730 |
| Preop ADL-independent, n (%) | 159 (88) | 49 (88) | 110 (88) | 0.924 |
| Tumor Location, n (%) | 0.499 | |||
| Left hemisphere | 85 (47) | 26 (46) | 59 (47) | – |
| Right hemisphere | 92 (51) | 28 (50) | 64 (51) | – |
| Cerebellar | 3 (2) | 2 (4) | 1 (1) | – |
| Spinal | 1 (1) | 0 | 1 (1) | – |
| Recurrent case, n (%) | 34 (19) | 12 (21) | 22 (18) | 0.686 |
| Surgery type, n (%) | 0.333 | |||
| Biopsy | 27 (15) | 11 (20) | 16 (13) | – |
| Resection | 154 (85) | 45 (80) | 109 (87) | – |
IQR interquartile range; KPS Karnofsky performance scale; ADL Activities of daily living. For all variables (with the exception of age and KPS), P-values were calculated from two-sided Chi-square statistics with Yates correction to compare the presence or absence of the specific biomarker in grade III versus grade IV gliomas. P-values were calculated from two-sided Mann-Whitney U test to compare the median age and KPS scores between grade III versus grade IV gliomas
Figures in boldface represent p values of less than 0.05