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. 2020 Jan 31;17:43. doi: 10.1186/s12974-020-1718-7

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Treatment with SR9009 decreases apoptosis and the loss of hippocampal neurons in the SE. a TUNEL-positive cells in the CA1 and CA3 regions of the hippocampus of the four groups in mice are displayed. b, c The number of TUNEL -positive cells in the CA1 and CA3 regions were calculated. Treatment with SR9009 after SE resulted in a diminished number of TUNEL-positive cells in the CA1 and CA3 regions. d, e A representative immunoblot showing protein immunoreactivity for cleaved caspase-3 (17 kDa) in the hippocampus of the four groups. A significant decrease in the cleaved-caspase3 level was observed in the SR9009-treated pilocarpine group compared to the vehicle-treated pilocarpine group. e NeuN immunofluorescence staining in the CA1, CA3, and DG regions of the hippocampus in the four groups. f, g The number of NeuN-positive cells in the SR9009-treated pilocarpine group was significantly higher than that in the vehicle-treated pilocarpine group. h SR9009 did not affect the number of NeuN-positive cells in the DG after SE. n = 3 for each group. The data presented as the mean ± SD. NS, not significant, *p < 0.05, ^†p < 0.001. Scale bar = 50 μm (a, e)