Table 3.
Fixed effect estimators for the 2-level random intercept linear model with level 1 units (measurements/visits) nested into level 2 units (n = 33 subjects with COPD), with FEV1% predicted as the dependent variable and Nrf2, HO-1 and GCLC mRNA, plasma GSH, plasma 8-iso as independent variables (fixed effects)
| Dependent variables | Beta Coefficients | P-value | 95%CI |
|---|---|---|---|
| Nrf2/beta actin mRNA | 8.31 | < 0.001 | 4.72;11.91 |
| HO-1/beta actin mRNA | 1.84 | 0.441 | −2.84;6.53 |
| GCLC/beta actin mRNA | 6.40 | 0.118 | −1.63;14.44 |
| plasma GSH (μmol/L) | 0.03 | 0.785 | −0.18;0.24 |
| plasma 8-iso (pg/ml) | −0.01 | 0.284 | −0.02;0.01 |
Legend: The model was adjusted also for age, sex, smoking status, smoking history (pack year), BMI and follow-up time