Table 1.
Breed | Chr | Start | End | Number of suggestive and significant SNPs | Most significant SNP | p-value | Allele frequency of + allele | Candidate genes within this QTL | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
AA | CH | HE | LM | SI | ||||||||
AA | 1 | 72069526 | 130071811 | 8 | 120584401a | 3.69 × 10−6 | 0.940 | 0.940 | 0.061 | 0.949 | 0.951 | DLG1, FAM43A, APOD, OPA1, OSTN, GHSR |
8 | 72017409 | 73103211 | 16 | 72569526b | 3.25 × 10−6 | 0.276 | 0.565 | 0.264 | 0.332 | 0.687 | ADAM28 | |
10 | 5155837 | 6179062 | 11 | 5655837d | 7.60 × 10−6 | 0.032 | 0.133 | 0.000 | 0.073 | 0.036 | SFXN1, DRD1e | |
23 | 20541063 | 21541072 | 2 | 21041063b | 3.34 × 10−7 | 0.995 | 0.977 | 0.000 | 0.000 | 0.005 | PTCHD4e | |
24 | 35913368 | 37107434 | 16 | 36567715a | 8.07 × 10−7 | 0.918 | 0.050 | 0.958 | 0.941 | 0.903 | ENOSF1, ADCYAP1 | |
CH | 2 | 35194 | 10711228 | 5128 | 6808074a | 9.07 × 10−49 | 0.000 | 0.079 | 0.000 | 0.028 | 0.004 | WDR75f, ASNSD1f, ARHGEF4f, MYO7Bf, IWS1e, NAB1f, MFSD6f, MSTNf, PMS1f, ORMDL1e, COL3A1f, COL5A2f, ANKARf, SLC40A1f |
4 | 89299122 | 90487119 | 12 | 89799122a | 4.67 × 10−6 | 0.000 | 0.007 | 0.002 | 0.000 | 0.992 | GPR37e, POT1 | |
14 | 33353270 | 34360874 | 4 | 33855595a | 2.20 × 10−7 | 0.013 | 0.026 | 0.054 | 0.054 | 0.982 | PREX2 | |
21 | 34538609 | 35572213 | 47 | 35062974b | 9.70 × 10−7 | 0.617 | 0.521 | 0.594 | 0.000 | 0.451 | UBL7, SEMA7A, PML | |
28 | 15669176 | 18516719 | 77 | 16273851a | 2.95 × 10−8 | 0.574 | 0.827 | 0.580 | 0.416 | 0.520 | ANK3, CDK1, RHOBTB1 | |
HE | 1 | 68813144 | 73614763 | 228 | 69348458b | 5.23 × 10−7 | 0.764 | 0.531 | 0.237 | 0.317 | 0.480 | KALRNe, ITGB5e |
7 | 83591608 | 84673367 | 26 | 84122153a | 3.16 × 10−7 | 0.177 | 0.851 | 0.913 | 0.000 | 0.910 | ACOT12, ATG10 | |
12 | 48965278 | 50129513 | 4 | 49465278a | 1.84 × 10−6 | 0.020 | 0.995 | 0.996 | 0.983 | 0.000 | KLF12 | |
13 | 2761800 | 3761897 | 2 | 3261897a | 7.44 × 10−7 | 0.681 | 0.761 | 0.795 | 0.269 | 0.695 | MRPL33 | |
23 | 12056019 | 13111217 | 5 | 12571991b | 1.09 × 10−6 | 0.220 | 0.000 | 0.094 | 0.885 | 0.100 | GLO1, GLP1R | |
LM | 2 | 4293223 | 12640428 | 2610 | 6622189a | 3.22 × 10−30 | 0.491 | 0.447 | 0.250 | 0.043 | 0.799 | WDR75, ASNSD1f, MYO7B, IWS1, NAB1f, MFSD6e, MSTNf, PMS1f, ORMDL1e, COL3A1f, COL5A2f, ANKARf, SLC40A1f, ZNF804A |
2 | 13916060 | 14987913 | 113 | 14446207bc | 4.83 × 10−8 | 0.567 | 0.562 | 0.374 | 0.394 | 0.523 | PDE1Ae, PPP1R1C | |
5 | 59612855 | 60696179 | 7 | 60112855a | 1.58 × 10−7 | 0.000 | 0.000 | 0.000 | 0.997 | 0.996 | AMDHD1 | |
11 | 12163298 | 13181229 | 7 | 12676690a | 1.56 × 10−6 | 0.486 | 0.283 | 0.000 | 0.231 | 0.163 | CYP26B1, DYSF, ZNF638 | |
SI | 6 | 76112104 | 77238886 | 16 | 76612104a | 1.28 × 10−6 | 0.997 | 0.993 | 0.000 | 0.000 | 0.993 | ENSBTAG00000043492 |
7 | 103195804 | 104247192 | 3 | 103695804b | 1.78 × 10−6 | 0.000 | 0.000 | 0.000 | 0.005 | 0.005 | SLCO4C1e, SLC06A1 | |
9 | 65068999 | 66303927 | 4 | 65712927a | 4.56 × 10−7 | 0.000 | 0.000 | 0.000 | 0.003 | 0.996 | TBX18e, MRAP2 | |
23 | 41204249 | 42287354 | 9 | 41747427a | 1.48 × 10−7 | 0.009 | 0.008 | 0.994 | 0.962 | 0.990 | JARID2 | |
25 | 22649471 | 23937019 | 6 | 23400365a | 1.00 × 10−7 | 0.985 | 0.993 | 0.000 | 0.993 | 0.998 | AQP8, ZKSCAN2 |
SNP classification: aintergenic, bintron, cupstream gene variant ddownstream gene variant
Significance of SNPs within genes: egene contained at least one suggestive SNP, fgene contained at least one significant SNP