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. 2020 Jan 30;52:2. doi: 10.1186/s12711-020-0523-1

Table 1.

Location of the most significant QTL, limited to the top five per breed, which were associated with development of hind quarter and the genes located within these QTL within each breed

Breed Chr Start End Number of suggestive and significant SNPs Most significant SNP p-value Allele frequency of + allele Candidate genes within this QTL
AA CH HE LM SI
AA 1 72069526 130071811 8 120584401a 3.69 × 10−6 0.940 0.940 0.061 0.949 0.951 DLG1, FAM43A, APOD, OPA1, OSTN, GHSR
8 72017409 73103211 16 72569526b 3.25 × 10−6 0.276 0.565 0.264 0.332 0.687 ADAM28
10 5155837 6179062 11 5655837d 7.60 × 10−6 0.032 0.133 0.000 0.073 0.036 SFXN1, DRD1e
23 20541063 21541072 2 21041063b 3.34 × 10−7 0.995 0.977 0.000 0.000 0.005 PTCHD4e
24 35913368 37107434 16 36567715a 8.07 × 10−7 0.918 0.050 0.958 0.941 0.903 ENOSF1, ADCYAP1
CH 2 35194 10711228 5128 6808074a 9.07 × 10−49 0.000 0.079 0.000 0.028 0.004 WDR75f, ASNSD1f, ARHGEF4f, MYO7Bf, IWS1e, NAB1f, MFSD6f, MSTNf, PMS1f, ORMDL1e, COL3A1f, COL5A2f, ANKARf, SLC40A1f
4 89299122 90487119 12 89799122a 4.67 × 10−6 0.000 0.007 0.002 0.000 0.992 GPR37e, POT1
14 33353270 34360874 4 33855595a 2.20 × 10−7 0.013 0.026 0.054 0.054 0.982 PREX2
21 34538609 35572213 47 35062974b 9.70 × 10−7 0.617 0.521 0.594 0.000 0.451 UBL7, SEMA7A, PML
28 15669176 18516719 77 16273851a 2.95 × 10−8 0.574 0.827 0.580 0.416 0.520 ANK3, CDK1, RHOBTB1
HE 1 68813144 73614763 228 69348458b 5.23 × 10−7 0.764 0.531 0.237 0.317 0.480 KALRNe, ITGB5e
7 83591608 84673367 26 84122153a 3.16 × 10−7 0.177 0.851 0.913 0.000 0.910 ACOT12, ATG10
12 48965278 50129513 4 49465278a 1.84 × 10−6 0.020 0.995 0.996 0.983 0.000 KLF12
13 2761800 3761897 2 3261897a 7.44 × 10−7 0.681 0.761 0.795 0.269 0.695 MRPL33
23 12056019 13111217 5 12571991b 1.09 × 10−6 0.220 0.000 0.094 0.885 0.100 GLO1, GLP1R
LM 2 4293223 12640428 2610 6622189a 3.22 × 10−30 0.491 0.447 0.250 0.043 0.799 WDR75, ASNSD1f, MYO7B, IWS1, NAB1f, MFSD6e, MSTNf, PMS1f, ORMDL1e, COL3A1f, COL5A2f, ANKARf, SLC40A1f, ZNF804A
2 13916060 14987913 113 14446207bc 4.83 × 10−8 0.567 0.562 0.374 0.394 0.523 PDE1Ae, PPP1R1C
5 59612855 60696179 7 60112855a 1.58 × 10−7 0.000 0.000 0.000 0.997 0.996 AMDHD1
11 12163298 13181229 7 12676690a 1.56 × 10−6 0.486 0.283 0.000 0.231 0.163 CYP26B1, DYSF, ZNF638
SI 6 76112104 77238886 16 76612104a 1.28 × 10−6 0.997 0.993 0.000 0.000 0.993 ENSBTAG00000043492
7 103195804 104247192 3 103695804b 1.78 × 10−6 0.000 0.000 0.000 0.005 0.005 SLCO4C1e, SLC06A1
9 65068999 66303927 4 65712927a 4.56 × 10−7 0.000 0.000 0.000 0.003 0.996 TBX18e, MRAP2
23 41204249 42287354 9 41747427a 1.48 × 10−7 0.009 0.008 0.994 0.962 0.990 JARID2
25 22649471 23937019 6 23400365a 1.00 × 10−7 0.985 0.993 0.000 0.993 0.998 AQP8, ZKSCAN2

SNP classification: aintergenic, bintron, cupstream gene variant ddownstream gene variant

Significance of SNPs within genes: egene contained at least one suggestive SNP, fgene contained at least one significant SNP