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. 2020 Jan 30;52:2. doi: 10.1186/s12711-020-0523-1

Table 2.

Location of the most significant QTL, limited to the top 5 per breed which were associated with development of loin, and the genes located within these QTL within each breed

Breed Chr Start End Number of suggestive and significant SNPs Most significant SNP P-value Allele frequency of + allele Candidate genes within this QTL
AA CH HE LM SI
AA 1 39155170 40155196 3 39655188a 1.06 × 10−6 0.003 0.015 0.000 0.967 0.976
10 5741208 6752759 54 6241208a 3.45 × 10−6 0.181 0.105 0.090 0.773 0.872 GCNT4, HMGCR
11 21539414 22560915 4 22049725c 6.26 × 10−6 0.032 0.928 0.904 0.000 0.068 CDKL8, MAP4K3
15 53716499 55635294 27 55096343a 1.43 × 10−6 0.993 0.000 0.000 0.000 0.996 RAB6A, MRPL48, UCP2, UCP3d, PPME1, NEU3
19 12894306 13934964 9 13430257a 2.23 × 10−6 0.045 0.088 0.969 0.102 0.044 USP32, MYO19, ACACA
CH 1 142705947 143712126 78 143205947c 3.50 × 10−6 0.000 0.010 0.005 0.972 0.993 BACE2, RIPK4, PRDM15, C2CD2
2 37387 8714844 1728 6808074a 1.19 × 10−26 0.000 0.079 0.000 0.028 0.004 WDR75e, ASNSD1e, MFSD6e, MSTNe, PMS1e, ORMDL1, COL3A1e, COL5A2e, ANKARe, SLC40A1e
10 84923776 85960329 2 85423776a 4.45 × 10−7 0.000 0.007 0.000 0.000 0.024 PSEN1, ACOT2, ACOT4, DNAL1, ZNF410, FAM161B, COQ6
16 32025893 33120555 127 32558878a 4.12 × 10−7 0.975 0.884 0.135 0.898 0.093 SMYD3, KIF26B, EFCAB2
24 45933369 46937392 5 46437392b 1.20 × 10−6 0.000 0.006 0.012 0.000 0.019 PSTPIP2, ST8SIA5
HE 2 79648265 81037622 15 80168803b 1.42 × 10−6 0.000 0.994 0.996 0.987 0.997 STAT1, MYO1Bd, NABP1
4 3339555 4351559 4 3851559a 1.16 × 10−7 0.014 0.034 0.025 0.884 0.952 ENSBTAG00000044810
11 17934758 18942324 3 18442324a 1.11 × 10−6 0.876 0.011 0.011 0.964 0.988 CRIM1
16 75812761 76823259 3 76312761a 1.94 × 10−6 0.911 0.000 0.030 0.000 0.937 ENSBTAG00000044497
29 9233633 10275049 26 9733633a 1.80 × 10−6 0.650 0.417 0.304 0.378 0.801 EED, SYTL2, CREBZF, TMEM126A, TMEM126B
LM 2 5545383 8287013 748 6747317a 6.69 × 10−10 0.198 0.409 0.617 0.073 0.511 WDR75d, ASNSD1d, MFSD6, MSTNd, PMS1d, ORMDL1, COL3A1, COL5A2d, ANKARe, SLC40A1d
3 99009887 100073842 5 99509887b 5.78 × 10−7 0.041 0.000 0.047 0.934 0.883 CYP4X1, CYP4A22
5 71738658 72751064 6 72238658b 2.70 × 10−6 0.000 0.819 0.163 0.251 0.830 SYN3, TIMP3, MGC137211, MGC137014, LARGE1d
6 110629080 112106706 11 111176155a 3.30 × 10−7 0.126 0.868 0.898 0.830 0.211 HS3ST1
12 32803688 33961156 7 33461156b 5.12 × 10−7 0.000 0.000 0.000 0.997 0.975 USP12, SHISA2
SI 7 58665425 60243933 10 59590500a 3.37 × 10−7 0.002 0.016 0.046 0.000 0.990 SH3RF2d
8 90813081 91857894 14 91313081a 5.24 × 10−7 0.957 0.627 0.064 0.346 0.291 SPIN1, FBXW12
14 79527472 81070931 18 80091780b 3.45 × 10−7 0.908 0.052 0.981 0.114 0.070 E2F5
17 69082585 70268366 4 69646862b 1.04 × 10−7 0.975 0.010 0.987 0.992 0.003 PITPNBd
22 33231032 34644069 14 34044822b 9.77 × 10−9 0.000 0.960 0.946 0.000 0.004 FAM19A1, SUCLG2e, KBTBD8

SNP classification: aintergenic, bintron, cdownstream gene variant

Significance of SNPs within genes: dgene contains at least one suggestive SNP, egene contains at least one significant SNP