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. 2020 Jan 30;52:2. doi: 10.1186/s12711-020-0523-1

Table 3.

Location of the most significant QTL, limited to the top 5 per breed, which were associated with development of inner thigh, and the genes located within these QTL within each breed

Breed Chr Start End Number of suggestive and significant SNPs Most significant SNP P-value Allele frequency of + allele Candidate genes within this QTL
AA CH HE LM SI
AA 1 146687440 147685998 7 147187440b 9.55 × 10−7 0.988 0.712 0.073 0.179 0.631 TRAPPC10, COL18A1, SLC19A1, PCBP3e, COL6A1, COL6A2
4 69229353 70999401 38 70373241a 4.19 × 10−7 0.991 0.015 0.990 0.014 0.900 HOXA1, HOXA2, HOXA3, HOXA4, HOXA5, HOXA6, HOXA7, HOXA9, HOXA10, HOXA11, HOXA13
24 36998437 38030390 4 37530390bd 2.24 × 10−7 0.977 0.000 0.014 0.036 0.983 NDC80, EMILIN2e, MYOM1, MYL12A, MYL12B
25 35042698 36122096 6 35542698a 3.50 × 10−7 0.998 0.000 0.000 0.000 0.002 POLR2J, MYL10, ALKBH4, COL26A1
29 23787949 24826548 7 24290699a 1.82 × 10−7 0.048 0.043 0.937 0.939 0.919 SLC6A5, PRMT3
CH 2 7850 10711228 5075 6808074a 9.07 × 10−49 0.000 0.079 0.000 0.028 0.005 WDR75f, ASNSD1f, NAB1f, MFSD6f, MSTNf, PMS1f, ORMDLe COL3A1, COL5A2f, ANKARf, SLC40A1f
14 33353270 34360874 4 33855595a 2.20 × 10−7 0.013 0.026 0.054 0.054 0.018 ARFGEF1, CPA6, PREX2
14 67849241 68850085 4 6834924a 2.69 × 10−6 0.000 0.062 0.000 0.000 0.000 STK3, KCNS2, POP1, RPL30, MATN2
16 60443313 62320499 4 60943313a 6.72 × 10−6 0.904 0.230 0.063 0.853 0.821 RASAL2, ANGPTL1, TOR3A, ABL2, SOAT1
29 21313583 22460213 38 21917306a 3.58 × 10−6 0.000 0.989 0.000 0.978 0.000 GAS2, FANCF
HE 4 3924012 5000928 3 4424012a 4.05 × 10−7 0.755 0.032 0.082 0.000 0.939 ENSBTAG00000023806
7 72100887 73679002 67 72608186b 9.09 × 10−7 0.000 0.998 0.046 0.000 0.995 EBF1e, ADRA1B
13 6038290 8341939 9 7003978a 1.84 × 10−7 0.000 0.000 0.002 0.004 0.000 ESF1, NDUFAF5, FLRT3
14 57257740 58269158 3 57757740a 7.98 × 10−7 0.262 0.122 0.758 0.104 0.000 TRHR
25 37995664 39005834 3 38505834c 2.68 × 10−7 0.160 0.928 0.097 0.056 0.071 LMTK2, PMS2, EIF2AK1, USP42
LM 2 313343 3758925 102 3226165a 5.94 × 10−10 0.907 0.032 0.997 0.066 0.057 NIPA1, NIPA2e, ARHGEF4
2 4973733 11101064 2441 6747317a 2.20 × 10−28 0.802 0.409 0.617 0.074 0.490 WDR75, ASNSD1f, NAB1f, MFSD6e, MSTNf, PMS1f, ORMDL1e, COL3A1e, COL5A2f, ANKARf, SLC40A1f
2 11556240 12618550 36 12116324a 1.36 × 10−8 0.308 0.402 0.231 0.195 0.556 ZNF804A
2 13935604 14957932 55 14447892bc 1.67 × 10−6 0.433 0.562 0.374 0.394 0.524 PDE1Ae, PPP1R1C, NEUROD1
4 23124509 24137261 59 23630609b 2.52 × 10−7 0.096 0.027 0.996 0.994 0.010 AGMOe, MEOX2
SI 1 22558133 23622641 49 23117106a 5.21 × 10−6 0.949 0.043 0.866 0.060 0.870 ENSBTAG00000046369
14 79492849 80610485 17 80090294b 2.33 × 10−7 0.104 0.052 0.980 0.886 0.072 E2F5
17 21615210 22651417 8 22115210a 1.47 × 10−6 0.474 0.619 0.639 0.359 0.297 ENSBTAG00000044703
21 17057917 18336523 18 17836523a 5.30 × 10−8 0.003 0.010 0.000 0.000 0.997 ENSBTAG00000045960
22 33706576 34737653 10 34236342b 2.08 × 10−6 0.000 0.995 0.000 0.987 0.002 SUCLG2e, KBTBD8

SNP classification: aintergenic, bintron, cupstream gene variant, ddownstream gene variant

Significance of SNPs within genes: egene contains at least one suggestive SNP, fgene contains at least one significant SNP