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. 2020 Jan 30;52:2. doi: 10.1186/s12711-020-0523-1

Table 4.

Location of the most significant QTL, limited to the top 5 per breed, which were associated with thigh width, and the genes located within these QTL within each breed

Breed Chr Start End Number of suggestive and significant SNPs Most significant SNP P-value Allele frequency of + allele Candidate genes within this QTL
AA CH HE LM SI
AA 11 53741952 54849531 2 54349531a 2.65 × 10−6 0.017 0.047 0.000 0.997 0.994 CTNNA2
13 78082912 79223584 10 78722523b 2.99 × 10−7 0.191 0.232 0.866 0.157 0.108 ZNFX1, B4GALT5, SLC9A8f, UBE2V1
14 22612620 23619374 3 23116129a 1.99 × 10−6 0.026 0.994 0.074 0.962 0.971 OPRK1, ATP6V1H, RGS20
16 1654734 2669694 4 2169248a 5.14 × 10−6 0.986 0.980 0.985 0.056 0.979 ETNK2, GOLT1A, PPP1RI5B, PIK3C2B, NFASC
16 63066185 64073838 2 63066185d 4.07 × 10−6 0.027 0.948 0.991 0.072 0.000 ACBD6, STX6, MR1
CH 2 7850 10186234 1860 6808074a 4.09 × 10−25 0.000 0.079 0.000 0.028 0.004 WDR75g, ASNSD1g, NAB1g, MFSD6g, MSTNg, PMS1g, ORMDL1, COL3A1g, COL5A2g, ANKARg, SLC40A1g
9 12470065 13731582 11 12970065e 8.65 × 10−9 0.000 0.013 0.000 0.003 0.000 KHDC3Lg, EEF1A1
20 61727533 63246384 5 62296495b 7.78 × 10−9 0.997 0.010 0.000 0.000 0.000 CTNND2f, DAP, FAM173B
28 9234253 24087892 1025 16275379a 4.17 × 10−9 0.581 0.829 0.476 0.430 0.523 ANK3f, CDK1, RHOBTB1, EGR2
28 24331178 40249741 1322 26134688a 3.87 × 10−9 0.388 0.810 0.424 0.591 0.486 SIRT1, MYPNf, DNA2f, SLC25A16, SRGNf, COL13A1f, AIFM2, ADAMTS14f, SGLP1, PCBD1, SPOCK2f, ANAPC16f, DDIT4, MYOZ1
HE 5 17326996 18595093 3 18095093a 1.75 × 10−6 0.000 0.996 0.003 0.985 0.000 C5H12orf50, C5H12orf29, CEP290
7 75039465 75039465 2 75539465d 4.24 × 10−6 0.990 0.000 0.997 0.000 0.000 GABRA6f
10 87480123 88487031 3 87980123b 1.72 × 10−6 0.959 0.034 0.020 0.981 0.033 TTLL5f, TGFB3
20 35840468 37412173 5 36340468a 1.30 × 10−6 0.342 0.589 0.421 0.230 0.328 LIFR, EGFLAM, GDNF
20 39512041 41162914 10 40272197b 1.01 × 10−6 0.015 0.985 0.985 0.994 0.003 C1QTNF3, ADAMTS12f
LM 2 4973607 10670961 1526 7772897a 2.88 × 10−15 0.617 0.571 0.000 0.116 0.642 WDR75f, ASNSD1g, NAB1f, MFSD6f, MSTNf, PMS1f, ORMDL1, COL3A1, COL5A2, ANKARg, SLC40A1g
2 11570479 12640428 43 12083258a 1.01 × 10−7 0.561 0.205 0.057 0.097 0.809 ZNF804A
2 13916060 14952210 55 14450953b 1.92 × 10−6 0.434 0.565 0.374 0.394 0.477 PDE1Af, PPP1R1C
9 36716988 37719425 4 37216988a 6.31 × 10−7 0.245 0.649 0.547 0.247 0.286 HS3ST5
27 35767035 36785436 7 36267035c 8.03 × 10−6 0.057 0.000 0.998 0.997 0.000 SFRP1, GOLGA7, GPAT4, ANK1
SI 9 32996000 34105290 5 33604527b 4.82 × 10−7 0.969 0.980 0.981 0.985 0.019 NEPN, GOPC
14 76746937 78193017 13 77271966a 1.65 × 10−7 0.712 0.107 0.052 0.916 0.085 MMP16f, SLC2A5
24 17511696 18515510 3 18015356a 8.99 × 10−7 0.461 0.449 0.299 0.506 0.378 ENSBTAG00000045320, ENSBTAG00000011094
26 35041033 36071133 3 35541033a 1.97 × 10−6 0.000 0.006 0.004 0.994 0.995 AFAP1L2, ABLIM1, ATRNL1
29 47398869 48688066 30 47898869a 5.42 × 10−7 0.790 0.197 0.886 0.850 0.108 CCND1, FGF19, FGF4

SNP classification: aintergenic, bintron, cupstream gene variant, ddownstream gene variant, esynonymous gene variant

Significance of SNPs within genes: fgene contains at least one suggestive SNP, ggene contains at least one significant SNP