Table 4.
Breed | Chr | Start | End | Number of suggestive and significant SNPs | Most significant SNP | P-value | Allele frequency of + allele | Candidate genes within this QTL | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
AA | CH | HE | LM | SI | ||||||||
AA | 11 | 53741952 | 54849531 | 2 | 54349531a | 2.65 × 10−6 | 0.017 | 0.047 | 0.000 | 0.997 | 0.994 | CTNNA2 |
13 | 78082912 | 79223584 | 10 | 78722523b | 2.99 × 10−7 | 0.191 | 0.232 | 0.866 | 0.157 | 0.108 | ZNFX1, B4GALT5, SLC9A8f, UBE2V1 | |
14 | 22612620 | 23619374 | 3 | 23116129a | 1.99 × 10−6 | 0.026 | 0.994 | 0.074 | 0.962 | 0.971 | OPRK1, ATP6V1H, RGS20 | |
16 | 1654734 | 2669694 | 4 | 2169248a | 5.14 × 10−6 | 0.986 | 0.980 | 0.985 | 0.056 | 0.979 | ETNK2, GOLT1A, PPP1RI5B, PIK3C2B, NFASC | |
16 | 63066185 | 64073838 | 2 | 63066185d | 4.07 × 10−6 | 0.027 | 0.948 | 0.991 | 0.072 | 0.000 | ACBD6, STX6, MR1 | |
CH | 2 | 7850 | 10186234 | 1860 | 6808074a | 4.09 × 10−25 | 0.000 | 0.079 | 0.000 | 0.028 | 0.004 | WDR75g, ASNSD1g, NAB1g, MFSD6g, MSTNg, PMS1g, ORMDL1, COL3A1g, COL5A2g, ANKARg, SLC40A1g |
9 | 12470065 | 13731582 | 11 | 12970065e | 8.65 × 10−9 | 0.000 | 0.013 | 0.000 | 0.003 | 0.000 | KHDC3Lg, EEF1A1 | |
20 | 61727533 | 63246384 | 5 | 62296495b | 7.78 × 10−9 | 0.997 | 0.010 | 0.000 | 0.000 | 0.000 | CTNND2f, DAP, FAM173B | |
28 | 9234253 | 24087892 | 1025 | 16275379a | 4.17 × 10−9 | 0.581 | 0.829 | 0.476 | 0.430 | 0.523 | ANK3f, CDK1, RHOBTB1, EGR2 | |
28 | 24331178 | 40249741 | 1322 | 26134688a | 3.87 × 10−9 | 0.388 | 0.810 | 0.424 | 0.591 | 0.486 | SIRT1, MYPNf, DNA2f, SLC25A16, SRGNf, COL13A1f, AIFM2, ADAMTS14f, SGLP1, PCBD1, SPOCK2f, ANAPC16f, DDIT4, MYOZ1 | |
HE | 5 | 17326996 | 18595093 | 3 | 18095093a | 1.75 × 10−6 | 0.000 | 0.996 | 0.003 | 0.985 | 0.000 | C5H12orf50, C5H12orf29, CEP290 |
7 | 75039465 | 75039465 | 2 | 75539465d | 4.24 × 10−6 | 0.990 | 0.000 | 0.997 | 0.000 | 0.000 | GABRA6f | |
10 | 87480123 | 88487031 | 3 | 87980123b | 1.72 × 10−6 | 0.959 | 0.034 | 0.020 | 0.981 | 0.033 | TTLL5f, TGFB3 | |
20 | 35840468 | 37412173 | 5 | 36340468a | 1.30 × 10−6 | 0.342 | 0.589 | 0.421 | 0.230 | 0.328 | LIFR, EGFLAM, GDNF | |
20 | 39512041 | 41162914 | 10 | 40272197b | 1.01 × 10−6 | 0.015 | 0.985 | 0.985 | 0.994 | 0.003 | C1QTNF3, ADAMTS12f | |
LM | 2 | 4973607 | 10670961 | 1526 | 7772897a | 2.88 × 10−15 | 0.617 | 0.571 | 0.000 | 0.116 | 0.642 | WDR75f, ASNSD1g, NAB1f, MFSD6f, MSTNf, PMS1f, ORMDL1, COL3A1, COL5A2, ANKARg, SLC40A1g |
2 | 11570479 | 12640428 | 43 | 12083258a | 1.01 × 10−7 | 0.561 | 0.205 | 0.057 | 0.097 | 0.809 | ZNF804A | |
2 | 13916060 | 14952210 | 55 | 14450953b | 1.92 × 10−6 | 0.434 | 0.565 | 0.374 | 0.394 | 0.477 | PDE1Af, PPP1R1C | |
9 | 36716988 | 37719425 | 4 | 37216988a | 6.31 × 10−7 | 0.245 | 0.649 | 0.547 | 0.247 | 0.286 | HS3ST5 | |
27 | 35767035 | 36785436 | 7 | 36267035c | 8.03 × 10−6 | 0.057 | 0.000 | 0.998 | 0.997 | 0.000 | SFRP1, GOLGA7, GPAT4, ANK1 | |
SI | 9 | 32996000 | 34105290 | 5 | 33604527b | 4.82 × 10−7 | 0.969 | 0.980 | 0.981 | 0.985 | 0.019 | NEPN, GOPC |
14 | 76746937 | 78193017 | 13 | 77271966a | 1.65 × 10−7 | 0.712 | 0.107 | 0.052 | 0.916 | 0.085 | MMP16f, SLC2A5 | |
24 | 17511696 | 18515510 | 3 | 18015356a | 8.99 × 10−7 | 0.461 | 0.449 | 0.299 | 0.506 | 0.378 | ENSBTAG00000045320, ENSBTAG00000011094 | |
26 | 35041033 | 36071133 | 3 | 35541033a | 1.97 × 10−6 | 0.000 | 0.006 | 0.004 | 0.994 | 0.995 | AFAP1L2, ABLIM1, ATRNL1 | |
29 | 47398869 | 48688066 | 30 | 47898869a | 5.42 × 10−7 | 0.790 | 0.197 | 0.886 | 0.850 | 0.108 | CCND1, FGF19, FGF4 |
SNP classification: aintergenic, bintron, cupstream gene variant, ddownstream gene variant, esynonymous gene variant
Significance of SNPs within genes: fgene contains at least one suggestive SNP, ggene contains at least one significant SNP