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. 2020 Jan 30;52:2. doi: 10.1186/s12711-020-0523-1

Table 5.

Location of the most significant QTL, limited to the top 5 per breed, which were associated with width of withers, and the genes located within these QTL within each breed

Breed Chr Start End Number of suggestive and significant SNPs Most significant SNP P-value Allele frequency of + allele Candidate genes within this QTL
AA CH HE LM SI
AA 1 40642399 41670931 3 41142399b 2.49 × 10−6 0.997 0.998 0.009 0.991 0.000 EPHA6d
6 90992982 92064889 10 91513217a 2.34 × 10−9 0.008 0.019 0.009 0.995 0.005 EREG, AREG, RCHY1
14 9414135 10414890 9 9914135b 3.85 × 10−6 0.016 0.936 0.144 0.969 0.951 TG, KCNQ3d
14 17744843 18889304 16 18244843b 1.59 × 10−6 0.957 0.007 0.977 0.000 0.977 ANXA13, KLHL38, FBXO32
15 66035436 67113172 4 66535436b 3.42 × 10−7 0.004 0.996 0.930 0.003 0.992 APIP, PDHX
CH 2 218127 8714844 1227 6808074a 2.02 × 10−21 0.000 0.079 0.000 0.028 0.004 WDR75e, ASNSD1d, NAB1e, MFSD6e, MSTNe, PMS1e, ORMDL1, COL3A1e, COL5A2e, ANKARe, SLC40A1e
4 63740415 65180447 6 64680447a 3.32 × 10−7 0.000 0.003 0.000 0.000 0.991 NT5C3A, KBTBD2
14 67870173 68870239 7 68370173a 2.98 × 10−7 0.028 0.060 0.965 0.053 0.024 STK3, KCNS2, POP1, RPL30, MATN2
28 15669176 17454059 6 16943776a 1.52 × 10−8 0.640 0.868 0.525 0.690 0.729 ANK3, CDK1, RHOBTB1
28 31765108 33148059 7 32634467a 1.61 × 10−7 0.367 0.889 0.664 0.511 0.468 KCNMA1
HE 7 63750754 64814905 15 64309256b 1.46 × 10−7 0.022 0.949 0.008 0.011 0.009 RPS14, MYOZ3, ZNF300, GPX3d, ANXA6
11 89579990 90599173 5 90079990a 5.13 × 10−6 0.664 0.280 0.163 0.800 0.217 RNF144A, RSAD2
18 11547513 12549350 5 12047513a 4.85 × 10−6 0.479 0.565 0.507 0.532 0.446 GSE1, IRF8, FOXC2
20 25429449 27124758 9 25929649a 3.38 × 10−6 0.532 0.000 0.559 0.000 0.480 FST
26 32810942 33810987 3 33310942b 2.78 × 10−6 0.000 0.000 0.998 0.000 0.000 GPAM, ACSL5
LM 2 5547713 8495179 725 6622189a 8.77 × 10−12 0.490 0.447 0.250 0.043 0.800 WDR75, ASNSD1d, NAB1, MFSD6, MSTN, PMS1d, ORMDL1, COL3A1, COL5A2e, ANKARd, SLC40A1e
2 9053737 10527711 26 9559686a 1.53 × 10−6 0.464 0.504 0.213 0.127 0.456 ITGAV, ZC3H15
2 13916060 14957655 68 14450953b 6.10 × 10−8 0.433 0.564 0.626 0.394 0.479 PDE1Ad, PPP1R1C, NEUROD1
2 20539841 21539862 3 21039862a 6.85 × 10−10 0.000 0.000 0.000 0.998 0.000 HOXD1, HOXD3, HOXD4, HOXD9, HOXD10, HOXD11, HOXD12, HOXD13
6 19014612 21121181 13 19817910a 8.15 × 10−9 0.000 0.000 0.008 0.995 0.000 NPNT, GSTCDd
SI 1 79028842 80104503 3 79604503b 3.81 × 10−7 0.022 0.040 0.000 0.964 0.004 LPPd
4 57566849 58584434 5 58084434d 6.35 × 10−8 0.902 0.261 0.457 0.248 0.229 IMMP2Ld, LRRN3
9 32996000 34471196 16 33604527b 5.67 × 10−8 0.969 0.979 0.019 0.985 0.019 NEPN, GOPCd
12 28061051 29073791 3 28561051d 7.49 × 10−7 0.008 0.020 0.084 0.016 0.998 PDS5B
20 65137216 66168943 4 65668943a 1.76 × 10−7 0.000 0.009 0.000 0.977 0.007 FASTKD3, ADCY2d

SNP classification: aintergenic, bintron, cdownstream gene variant

Significance of SNPs within genes: dgene contains at least one suggestive SNP, egene contains at least one significant SNP