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. 2020 Jan 30;18:23. doi: 10.1186/s12951-019-0556-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 14 — Quantification of collagen fibril diameter of in vivo engineered tendons with native tendon as a control. Collagen fibril diameter of in vivo engineered tendons increased with time. There was significant difference between 12 and 21 weeks, between 21 and 45 weeks and between 12 and 45 weeks of the AMSCs seeded group (*P < 0.001). There was significant difference between two groups at 45 weeks post implantation (*P < 0.001). Exp experimental group, Ctrl control group, w week, NRAT normal rabbit tendon

(Reprinted with permission from [115])