Table 1.

Functional roles of hub genes with a degree ≥ 10

Gene symbol	Full name	Function
CDKN3	Cyclin-dependent kinase inhibitor 3	The protein was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with and dephosphorylate CDK2 kinase, thereby preventing the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers
CYP2C9	Cytochrome P450 family 2 subfamily C member 9	This gene encodes a member of the cytochrome P450 superfamily of enzymes. These monooxygenases catalyse many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids
LCAT	Lecithin-cholesterol acyltransferase	This gene encodes the extracellular cholesterol esterifying enzyme lecithin-cholesterol acyltransferase. Esterification of cholesterol is required for cholesterol transport