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. 2020 Feb;62(2):204–216. doi: 10.1165/rcmb.2019-0245OC

Figure 7.

Figure 7.

Effect of CP4715 on TGF-β signals in lung fibroblasts derived from patients with IPF. (A–C) Effects of periostin knockdown (A) or CP4715 (B and C) on expression at mRNA levels of SERPINE1, CTGF, IGFBP3, IL11, POSTN, FN1, and COL1A1 (A and B) or on phosphorylation of Smad3 (C). Lung fibroblasts derived from four patients with IPF were stimulated with or without 1 ng/ml of TGF-β for 24 hours in the presence of control or periostin siRNA (A) or 1 μM CP4715 from 24 hours before the TGF-β stimulation (B and C). In C, the data of one clone of lung fibroblasts derived from patients with IPF (IPF49) are depicted. The values were adjusted by GAPDH expression (A and B). **P < 0.01.