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Bleo reduces lung exposure of a P-gp substrate drug, nintedanib. Nintedanib (30 mg/kg) was orally administered to OP-bleo and SC-bleo mice 1 hour before animals were killed, then quantified in (A) plasma and (B) lung tissue via LC-MS/MS. n = 4 mice per group. *P < 0.05 indicates significant difference from control group.
